Molecular Formula | C25H37NO4 |
Molar Mass | 415.57 |
Density | 1.145±0.06 g/cm3(Predicted) |
Melting Point | 66-68°C |
Boling Point | 629.8±55.0 °C(Predicted) |
Flash Point | 334.7°C |
Solubility | Soluble in ethanol (~50 mg/ml), methanol, DMSO (~25 mg/ml), DMF (~25 mg/ml), and PBS ( |
Vapor Presure | 9.94E-17mmHg at 25°C |
Appearance | Crystalline solid |
Color | White to Off-White |
pKa | 14.25±0.20(Predicted) |
Storage Condition | -20°C |
Stability | Light Sensitive |
Refractive Index | 1.591 |
WGK Germany | 3 |
Reference Show more | 1. Pan Chen, Xu Yong, Han Jing, et al. Determination of bimatoprost in eyelash growth liquid cosmetics by high performance liquid chromatography-tandem mass spectrometry [J]. Journal of Analytical Testing, 2020(7). |
crystalline powder. Soluble in ethanol and methanol, slightly soluble in water.
with (3aR,4R,5R,6as)-hexahydro-4-(3-oxygen -5-phenyl-1E-pentenyl) -5-(p-phenyl butyryloxy)-2H-cyclopento [B] furan -2-ketone as raw material. After reduction, the carbonyl group on the furan ring is reduced to a hydroxyl group, which is hydrolyzed and then condensed with triphenylphosphine of valeric acid to obtain 7-[(1R,2R,3R,5S)-3,5-= hydroxy 2 A [(3 S) a 5 phenyl -3-[(tetrahydro-2-H-pyran-2-yl) oxy]-1E-pentenyl] cyclopentyl]-52-heptenoic acid. Hydrolysis removes the protecting group on the hydroxyl group of the pentenyl side chain. Methyl Ester was obtained by dissolving methyl iodide in dimethylformamide under the action of Cs2 C03, and finally reacted with an aqueous solution of ethylamine to obtain the product.
developed by Allergan, Inc., USA, was first launched in the United States in 2001. Prostaglandin F2 a stimulator. The product selectively mimics the action of prostacyclin produced in the body, lowering intraocular pressure by increasing aqueous humor flow in the scleral pathway of the microscleral network and the pigmented layer. It is used in patients with open-angle glaucoma, or in patients with elevated intraocular pressure who are ineffective with other intraocular pressure lowering drugs (cannot reach a predetermined level of intraocular pressure after multiple measurements) or cannot tolerate.